ADULT-TYPE HYPOLACTASIA: Genotype-phenotype correlation
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چکیده
منابع مشابه
Frequency of LCT -13910C>T single nucleotide polymorphism associated with adult-type hypolactasia/lactase persistence among Brazilians of different ethnic groups
BACKGROUND Adult-type hypolactasia, the physiological decline of lactase some time after weaning, was previously associated with the LCT -13910C>T polymorphism worldwide except in Africa. Lactase non-persistence is the most common phenotype in humans, except in northwestern Europe with its long history of pastoralism and milking. We had previously shown association of LCT -13910C>T polymorphism...
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Gastrointestinal symptoms are frequent in the adult working-age population. Sufferers often relate them to ingested food substances, especially cow’s milk. The purpose of this study was to evaluate subjective food-related gastrointestinal symptoms and their relation to cow’s milk. This was done by determining the genotype of adult-type hypolactasia, measuring antibodies against milk protein, an...
متن کاملImproving diagnosis of adult-type hypolactasia in patients with abdominal complaints.
BACKGROUND Adult-type hypolactasia is caused by genetic lactase non-persistence. It is the most common cause of lactose intolerance, which results in gastrointestinal symptoms after ingestion of dairy products. Currently, lactose intolerance is investigated by the hydrogen breath test (HBT), which is considered the preferred diagnostic test. Adult-type hypolactasia may also be diagnosed by geno...
متن کاملA genetic test which can be used to diagnose adult-type hypolactasia in children.
BACKGROUND/AIMS Adult-type hypolactasia (primary lactose malabsorption) affects most of world's human population and limits the use of fresh milk due to lactose intolerance. The diagnosis of adult-type hypolactasia has been difficult to establish because of unsatisfactory diagnostic methods. C/T(-13910) single nucleotide polymorphism residing 13910 base pairs from the 5' end of the lactase gene...
متن کاملEvaluation of a Genetic Test for Diagnose of Primary Hypolactasia in Northeast of Iran (Khorasan)
Objective(s) Primary or adult type hypolactasia, the most common enzyme deficiency in the world, is due to reduced lactase activity in the intestinal cell after weaning. Lactase non-persistence is inherited as an autosomal recessive trait. A DNA variant, single nucleotide polymorphism C/T−13910 which is located on 13910 base pairs (bp) upstream of the lactase gene (LCT) at chromosome 2 has been...
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